Wayne State University is one of the state's largest universities and, with its role as a partner with TechTown and NextEnergy, its research reach and national stature continues to grow. Add in the College for Creative Studies, which just opened a second campus, University of Detroit Mercy, which has Michigan's only Division 1 lacrosse team, and Marygrove College's impressive urban leadership work. All in all, not too shabby in the knowledge department for a blue-collar town.